Endocrine Abstracts

Aims: To determine whether single parenthood, special needs, ethnicity and indices of multiple deprivation 2007(proxy for social deprivation) influence metabolic control in T1DM.Methodology: Retrospective study (12 months) from 01/01/2007 till 31/12/2007. Data on several demographic and clinical variables were obtained from 105 children with T1DM from a single centre, after applying explicit exclusion criteria. Glycaemic control was assessed using HbA1c ...

Background: Childhood obesity is increasingly associated with type 2 diabetes (T2D). Metformin reduces the risk for T2D in adult obese non-diabetic patients, but the evidence in obese children and young people (CYP) is inconclusive.Design: The metformin in obese children and adolescents (MOCA) trial was a prospective, multi-centre, randomized, double-blind, placebo-controlled trial of 1.5 g metformin daily in CYP with raised fasting or post-prandial insu...

Background and objective: Childhood obesity is associated with reduced insulin sensitivity and increased risk for type 2 diabetes (T2D). The objective of the MOCA trial was to investigate the effect of metformin in severely obese children and adolescents.Design and Methods: In a six month multi-centre randomized, double-blind placebo-controlled trial metformin (1.5 g daily) or placebo was given to children and adolescents (8–18 years) with insulin r...